@article{MAKHILLRJMS202216112281,
    title = {Treatment of Acne Vulgaris with Adaplane-Benzoyl Peroxide Topical Gel Formulation and
Control and the Effects of Treatment Psychology},
    journal = {Research Journal of Medical Sciences},
    volume = {16},
    number = {1},
    pages = {9-14},
    year = {2022},
    issn = {1815-9346},
    doi = {rjmsci.2022.9.14},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=rjmsci.2022.9.14},
    author = {Monireh},
    keywords = {Acne treatment,adapalene topical gel control,benzoyl peroxide,vulgaris},
    abstract = {Binary vulgaris is a very common disease
among adolescents. Due to the effects it has on people's
faces, it can impose many social and psychological
costs on patients, so the treatment of this disease in
addition to a health need is a social necessity. It is
psychological. Therefore, in this study, Adapalene 0.1%
and benzoyl peroxide 2.5% in a gel formulation were
formulated for the first time in IRAN to guarantee
better results and increase patients' acceptance of these
two drugs at the same time. In the first stage, several
formulations will be prepared using various jellies,
which contain both benzoyl peroxide and adapalene, as
well as other compounds such as hemoquantum,
protective, etc. In the second stage, the various
formulations prepared will be tested for
physicochemical control. Control tests include
determining the amount of active ingredient, checking
for release simultaneously with the manufacture of the
products, accelerated stability tests will be performed
on the formulation to select the desired formulation
based on the results of the control tests. In this work, we
made eighty formulations, of which three formulations
had the best physical and functional stability. Among
them, la formulation was determined as the superior
formulation and various physicochemical and microbial
tests were performed on this formulation, all of which
will confirm the superior product production method.}
    }