@article{MAKHILLRJMS20115611821,
    title = {<I>In vitro</I> Cytotoxic Pentacyclic Triterpenoids of <I>Newbouldia laevis</I>},
    journal = {Research Journal of Medical Sciences},
    volume = {5},
    number = {6},
    pages = {330-335},
    year = {2011},
    issn = {1815-9346},
    doi = {rjmsci.2011.330.335},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=rjmsci.2011.330.335},
    author = {P.A.,D.A.,H.C. and},
    keywords = {Bignoniaceae,fibroblasts,cytotoxicity,bioactivity,ursenoic acid,oleanenoic acid},
    abstract = {Bioactivity directed fractionation afforded four cytotoxic constituents from the bioactive methanolic leaf extract (LD<SUB>50</SUB> 30 &#956;g mLG<SUP>1</SUP>) of<I> Newbouldia laevis</I> (Bignoniaceae) collected from Ibadan, Nigeria. Four pentacyclic triterpenoids namely 2&#945;, 3&#946;, 19&#945;-trihydroxy-12-ursen-28-oic acid, 3&#946;, 19&#945;-dihydroxy-12-ursen-28-oic acid, 3&#946;-hydroxy-12-ursen-28-oic acid, 3&#946;-hydroxy 12-oleanen-28-oic acid were found to be the cytotoxic principles. These compounds demonstrated significant cytotoxicity <I>in vitro</I> against ST-57 brain tumor transformed fibroblasts with LD<SUB>50</SUB> ranging from 0.4 &#956;g mLG<SUP>1</SUP> (compound 1) to 4 &#956;g mLG<SUP>1</SUP> (compound 4). These ursene and oleanene type triterpenoids are encountered for the first time in this plant. The structures of these compounds were established by spectral data.}
    }