@article{MAKHILLRJMS20082411627,
    title = {Plasma Biochemical Parameters as Surrogate Prognostic Markers in HIV-1 Infected Patients},
    journal = {Research Journal of Medical Sciences},
    volume = {2},
    number = {4},
    pages = {163-165},
    year = {2008},
    issn = {1815-9346},
    doi = {rjmsci.2008.163.165},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=rjmsci.2008.163.165},
    author = {O.A. Ajose,S.O. Banjoko,O.A. Olasode,V.A. Oyegunle and},
    keywords = {HIV-1,surrogate marker,prognosis,markers,infected patients},
    abstract = {The depression of the immune system accompanied by different metabolic derangements which are worsened by secondary infections are responsible for morbidity and subsequent mortality in HIV-1 infected patients. While, the gold standard prognostic marker for the infection remains the CD4+T lymphocyte count, plasma biochemical markers are potential surrogate prognostic markers. Samples obtained from 100 consecutively diagnosed HIV-1 infected patients who were not on anti retroviral therapy and equal number of apparently healthy seronegative individuals as controls were analysed for urea, creatinine total protein, albumin, globulin and albumin: globulin ratio using kits obtained from Randox laboratorie, U.K. spectrophotometrically and Na+, K+ and HCO<SUB>3</SUB> ions concentration using the ion selective electrode analyzer. obtainable from Hitachi, Japan. Compared to the controls, statistically significant differences were observed in the plasma concentrations of HCO<SUB>3</SUB> (p&lt;0.001) urea (p&lt;0.005) creatinine (p&lt;0.001), total protein (p&lt;0.001), albumin (p&lt;0.0001) globulin (p&lt;0.001) and albumin: Globulin ratio (p&lt;0.0001). However, no significant difference were observed in the Na+ and K+ ion concentrations with p values of 0.10 and 0.25, respectively. Those significantly different plasma biochemical parameters can therefore be useful surrogate prognostic markers for HIV-1 infections in resource limited settings.}
    }