@article{MAKHILLRJMS2024181231864,
    title = {An Observational Study of Changes in the Coagulation Profile of Patients Undergoing Laproscopic Cholecystectomy Using Carbondioxide Pneumoperitoneum},
    journal = {Research Journal of Medical Sciences},
    volume = {18},
    number = {12},
    pages = {993-997},
    year = {2024},
    issn = {1815-9346},
    doi = {makrjms.2024.12.993.997},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=makrjms.2024.12.993.997},
    author = {Idireddy,K.L.,Channanna and},
    keywords = {Laparoscopic cholecystectomy, carbon dioxide pneumoperitoneum},
    abstract = {Onearoscopy is a widely utilized diagnostic and therapeutic procedure. It
offers several advantages over traditional open surgical methods,
including improved cosmetic outcomes, reduced postoperative pain,
expedited hospital discharge, and a faster return to normal activities and
work. Consequently, this study aimed to examine the effects of carbon
dioxide pneumoperitoneum on the coagulation system in patients
undergoing laparoscopic surgery (LC) and to enhance surgeons'
awareness of any potential adverse effects. This prospective, time‐bound
study was conducted in the Department of General Surgery at PESIMSR
Hospital, Kuppam, over a period of 18 months (2022‐2024). The study
sample comprised 55 participants. Inclusion criteria encompassed
patients who underwent laparoscopic cholecystectomy, aged between 18
and 60 years, with gallstones and gallbladder polyps, patients with
chronic cholecystitis, those in the recovery stages of acute cholecystitis,
surgeries lasting between 90‐180 minutes, and patients who provided
consent for participation. In this study, the mean D‐DIMER level was 0.27
± 0.04 pg/ml prior to surgery. A significant increase in D‐DIMER levels was
observed 30 minutes and 6 hours post‐surgery. Additionally, prothrombin
time (PT) increased significantly 30 minutes and 6 hours after
pneumoperitoneum. A significant increase in activated partial
thromboplastin time (APTT) values was also noted post‐surgery. There
was a notable increase in prothrombin time following
pneumoperitoneum, as well as an increase in APTT after surgery. A
significant rise in D‐dimer levels was also observed.}
    }