@article{MAKHILLRJMS2024181231788,
    title = {Analysis of the Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux Disease: A Clinical Evaluation in a South Indian Population},
    journal = {Research Journal of Medical Sciences},
    volume = {18},
    number = {12},
    pages = {815-819},
    year = {2024},
    issn = {1815-9346},
    doi = {makrjms.2024.12.815.819},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=makrjms.2024.12.815.819},
    author = {G.,B. and},
    keywords = {Laryngopharyngeal reflux, proton pump inhibitors, RSI, RFS, South India, lifestyle modifications},
    abstract = {Laryngopharyngeal Reflux (LPR), an extra-esophageal manifestation of
GERD, presents with nonspecific symptoms and often lacks classical GERD
features. Proton Pump Inhibitors (PPIs) are widely used in LPR treatment,
though their effectiveness remains debated. This study evaluates the
clinical efficacy of PPI therapy in LPR management in a South Indian
population. A prospective quasi-experimental study was conducted over
six months in a tertiary center in South India. Adults aged 18-60 years
with clinical symptoms of LPR (RSI $13 and RFS >7) were prescribed
pantoprazole 40 mg twice daily for 8 weeks. RSI and RFS scores were
assessed pre- and post-treatment. Lifestyle modifications were also
documented. Data were analyzed using paired t-tests and logistic
regression. Among 100 participants (mean age 38.6±10.5 years, 56%
female), the mean RSI score improved from 20.8 to 10.2 and RFS from 9.7
to 5.2 (p<0.001). Complete response (RSI <13 and RFS <7) was seen in
58%, partial in 28% and no response in 14%. Lifestyle modifications
significantly improved treatment outcomes (p<0.01). Logistic regression
identified symptom severity and lifestyle adherence as independent
predictors of treatment response. PPI therapy significantly improves
symptoms and laryngoscopic findings in LPR patients, particularly when
combined with lifestyle changes. A tailored, multifactorial approach is
essential for optimal management of LPR in Indian settings.}
    }