@article{MAKHILLRJAS201813410085,
    title = {The Role of Alpha-1 Antitrypsin Enzyme on Pulmonary Dysfunction
Due to Exposure to NO<sub>2</sub>},
    journal = {Research Journal of Applied Sciences},
    volume = {13},
    number = {4},
    pages = {229-234},
    year = {2018},
    issn = {1815-932x},
    doi = {rjasci.2018.229.234},
    url = {https://makhillpublications.co/view-article.php?issn=1815-932x&doi=rjasci.2018.229.234},
    author = {Bambang,Satria,Haryoto and},
    keywords = {NO2,AAT,FEV1,FVC,traffic police,Jakarta,Indonesia},
    abstract = {Nitrogen dioxide (NO<sub>2</sub>) is one of the air pollutants whose concentration is increasing due to the 
increased number of vehicles as a mode of transportation. Exposure to NO<sub>2</sub> causes physical symptoms of
respiratory disorders and lung function and Alpha 1 Antitrypsin (AAT) plays a role in the protection of
inflammation due to exposure to NO<sub>2</sub> through inactivation by nitrogen. This study aims to reveal the 
relationship of NO<sub>2</sub> exposure, AAT and lung function of the traffic police in Jakarta. It is a cross sectional study 
with 112 traffic police as research subjects divided into two groups: the police working on the highway and
working in the office. NO<sub>2</sub> measurement of the environment is carried out at the location where the subjects 
work and examination is done toward lung physiology, AAT levels, body weight, body fat percentage, height
and waist circumference as a factor in determining lung function. NO<sub>2</sub> levels are 18.72 ppb on highways (high 
exposure areas) and 4.14 ppb in the office (low exposure area), respectively. There are 49% of the traffic police
working on the highway (high exposure to NO<sub>2</sub> ) and 51% of police officers working in the office (low exposure 
to NO<sub>2</sub> ). Mean of pulmonary physiology, represented by percentage of FVC (Forced Vital Capacity), on the 
entire subject is 89.49 and mean of FEV<sub>1</sub> (Forced Expiratory Volume in 1 sec) is 95.39. The mean of FEV<sub>1</sub>
compared to FVC is 88.4 and there is no significant difference between police officers working in the highway
and working in the office. AAT levels in both subjects show normal values compared to normal levels of AAT
standard of 141.07 mg/dL. Finally, the prediction model obtained in the end which is the prediction of FVC
percentage and FEV<sub>1</sub> percentage for both the dependent variable has a normal distribution. In conclusion, the
value of lung function for police officers working on the roads is lower than the value of lung function of those
working in the office. Factors that affect lung function in this study are NO<sub>2</sub> levels, AAT, fat, age (35 years old), 
visceral fat and waist circumference.}
    }