@article{MAKHILLRJAS2008328901,
    title = {Anti-Hyperglycemic and Hypolipidemic Effect of Ethanolic Extract of <I>Chrysophyllum albidum</I> Seed Cotyledon in Alloxan Induced-Diabetic Rats},
    journal = {Research Journal of Applied Sciences},
    volume = {3},
    number = {2},
    pages = {123-127},
    year = {2008},
    issn = {1815-932x},
    doi = {rjasci.2008.123.127},
    url = {https://makhillpublications.co/view-article.php?issn=1815-932x&doi=rjasci.2008.123.127},
    author = {O.S. Olorunnisola,S. Amao,L.O. Ehigie and},
    keywords = {Diabetes Mellitus,Chrysophyllum albidum seed cotyledon,alloxan,hyperglycaemic,lipid profile},
    abstract = {The present study evaluate the anti-hyperglycemic and hypolipidemic effect of ethanolic extract prepared from <I>Chrysophyllum albidum</I> seed cotyledon in model of alloxan-induced diabetic rats. Results showed that the daily treatment of diabetic rats with ethanolic extract of <I>Chrysophyllum albidum</I> seed cotyledon twice daily for 7 days (100 and 200 mg kg <SUP>1</SUP> orally) significantly decreased (p&lt;0.001) the blood glucose levels by 11.92 and 12.10%, respectively in the treated induced diabetic rats compared to the diabetic control rats. The 100 mg kg <SUP>1</SUP> dose of the extract showed insignificant decrease in the hepatic lipids (except HDL-cholesterol) concentrations, while the 200 mg kg <SUP>1</SUP> of the extract showed a significant decrease (p&lt;0.001) in the hepatic lipids (except HDL-cholesterol) in the treated diabetic rats and treated non-diabetic rats. However, the various doses of the extract significantly increased (p&lt;0.001) the HDL-cholesterol in treated diabetic rats while, there was no significant effect on the hepatic HDL-cholesterol in the treated non-diabetic rats. The results justify the popular use of <I>Chrysophyllum albidum</I> seed cotyledon, pointing out to the potential benefit of the plant ethanolic extract in alternative medicine in the treatment of diabetes mellitus.}
    }