@article{MAKHILLRJBS201813111499,
    title = {Anti-α-Glucosidase, Anti-α-Amylase and Anti-Inflammatory Effects of
Leaf Extracts of <i>Ziziphus Spina-christi</i> (Sedr) Grown in Jordan},
    journal = {Research Journal of Biological Sciences},
    volume = {13},
    number = {1},
    pages = {1-7},
    year = {2018},
    issn = {1815-8846},
    doi = {rjbsci.2018.1.7},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2018.1.7},
    author = {Sabah},
    keywords = {Ziziphus spina-christi,anti-&alpha;-glucosidase,anti-&alpha;-amylase,anti inflammation,extract,diabetes,inflammation},
    abstract = {<i>Ziziphus Spina-christi</i> is a famous plant in Jordan available in different regions. It is used traditionally
for the treatment of several pathologies. The aim of this study is to investigate and compare the <i>in vitro</i> &alpha;-glucosidase, &alpha;-amylase and inflammation inhibitory activities for different concentration of methanolic
and ethanolic leaf extracts of <i>Z. Spina-christi</i>. Fresh leaves of <i>Z. Spina-christi</i> were collected and
subjected to methanolic and ethanolic extraction and were investigated for their anti-&alpha;-glucosidase, anti-&alpha;-amylase and anti-inflammatory activities. Methanolic extract seems to be a strong potent in both
enzymes inhibitory potential compared to ethanolic. The calculated IC<sub>50</sub> were 8.9 and 305.6 &mu;g/ml against &alpha;-glucosidase activity and 39.12 and 318.4 &mu;g/ml against &alpha;-amylase activity for methanolic and
ethanolic leaf extracts, respectively. Anti-inflammatory activity, using protein denaturation method, showed
that methanolic extract exhibited a highest anti inflammatory effect compared with ethanolic extract and the
standard. At the concentration of 100 &mu;g/ml, the anti inflammatory effect were 95.3, 25.2 and 20.2% for
methanolic extract, ehanolic extract and standard diclofenac sodium, respectively. This study support and
agree with the traditional usage of plants of <i>Z. Spina-christi for the control of diabetes and inflammation.}
    }