@article{MAKHILLRJBS20149211433,
    title = {Collagen-Calcium Alginate Film Dressing with Therapeutic Ultrasound to Treat Open Wound in Rats},
    journal = {Research Journal of Biological Sciences},
    volume = {9},
    number = {2},
    pages = {57-61},
    year = {2014},
    issn = {1815-8846},
    doi = {rjbsci.2014.57.61},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2014.57.61},
    author = {M.A.,A.,H.,M. and},
    keywords = {Ultrasound,collagen,calcium alginate,wound,biomaterials,tissues},
    abstract = {About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were 
  used in this study over a 20 day period. They were allocated randomly into 4 
  groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was 
  control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic 
  ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate 
  film with therapeutic ultrasound. On application, the collagen-calcium alginate 
  film with therapeutic ultrasound was well accepted by the animals without any 
  adverse reaction. Mean percentage of wound contraction were significantly better 
  in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium 
  alginate film with therapeutic ultrasound treated group as compared to the other 
  groups. Collagen is a biocompatible protein that does not interfere with the 
  body’s normal immunologic response and can be used in non-healing chronic 
  wounds which require a trigger to stimulate the normal healing process. In extensive 
  wounds when there is lack of autologous tissue, biomaterials like collagen-calcium 
  alginate may be beneficial and can be used.}
    }