@article{MAKHILLRJBS201051211203,
    title = {Anti Inflammatory Effect of Grape Seed (<I>Vitis vinifera</I>) Extract on Formalin-Induced Edema in Rat Paw},
    journal = {Research Journal of Biological Sciences},
    volume = {5},
    number = {12},
    pages = {760-763},
    year = {2010},
    issn = {1815-8846},
    doi = {rjbsci.2010.760.763},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2010.760.763},
    author = {Hemmati,Arzi and},
    keywords = {Grape seed,inflammation,rat paw edema,Vitis vinifera,injection,Iran},
    abstract = {Several studies have shown that grape seed extract possess anti-inflammatory effect because of its components such as procyanidine. The purpose of this study was the investigation of the anti-inflammatory effect of grape seed extract on formalin-induced edema in rat paw. Hydroalcohlic extract of grape seed (<I>Vitis vinifera</I>) was prepared using maceration method. Albino rats weighting 180-200 g were divided in to 5 groups as intraperitoneal GSE receiving (200, 400 and 600 mg kg<SUP>-1</SUP>), positive control (indomethacin 5 mg kg<SUP>-1</SUP> p.o.) and negative control (normal saline 5 mg kg<SUP>-1</SUP> IP), 30 min following IP injection of GSE or indomethacin administration 0.1 mL of formalin (2.5% w/v) was injected in rat hind paw and the changes in rat's paw volume was assessed by plethysmometer for 3 h at intervals of 1 h. Grape seed extract (200, 400 and 600 mg kg<SUP>-1</SUP>, IP) exerted anti-inflammatory effect in a dose dependent manner. Hydroalcoholic seed extract in dose of 600 mg kg<SUP>-1</SUP> was more effective against formalin-induced paw inflammation. However, this effect was less potent than indomethacin (5 mg kg<SUP>-1</SUP>) effect as positive control.}
    }