@article{MAKHILLRJBS201051011159,
    title = {The Effect of Cerebral Ventricular Injection Extract of <I>Myristica Fragrans </I>on Fear Behavior in Male Adult Rats of Wistar},
    journal = {Research Journal of Biological Sciences},
    volume = {5},
    number = {10},
    pages = {656-663},
    year = {2010},
    issn = {1815-8846},
    doi = {rjbsci.2010.656.663},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2010.656.663},
    author = {K.,G.H. and},
    keywords = {coparison,elevated plus-maze,Iran,injection of cerebral ventricular,Myristica fragrans,Fear},
    abstract = {<I>Myristica fragrans</I> plant is one of the herbal plants which has medical and cure effects on nerves. By pay attention to the disadvantages of the psychological drugs for body, the researchers want to have a research on the relations between these drugs and fear. In this study, the researchers put extract of <I>Myristica fragrans</I> (50%) with the 24.53% humidity is the values of (600,300.150 &#956;g per rat) with six sample that each with the value of 1 &#956;L. In the control group, they inject 1 micro L saline to the injection of cerebral ventricular. Also in other positive control group, 20 mg kg<SUP>-1</SUP> Pentylenetetrazol (PTZ) inject to the Intra Peritoneum (IP) after these injections, they evaluate the fear behaviors with the Elevated plus-maze test. The results of this test shows that PTZ is as the positive control group (p&lt;0.05) can increase the residence time in the close arm more than the saline control group. In comparison, the extract of <I>Myristica fragrans</I> is all doses could increase the specified criteria and decrease the residence time in the open arm. But to the statistical way, two doses (600, 300 &#956;g per rat) have the various levels (p&lt;0.05), the saline control group. But when the extract of <I>Myristica fragrans</I> with PTZ was injected to the animal, it reduced the operation of PTZ. In fact, the maximum dose of extract (600 &#956;g per rat) could show variation to the positive control group PTZ.}
    }