@article{MAKHILLRJBS20105111056,
    title = {Central Injections of β-Endorphin Fragment Modulate theAnorexia by Insulin in Neonatal Chicks},
    journal = {Research Journal of Biological Sciences},
    volume = {5},
    number = {1},
    pages = {64-67},
    year = {2010},
    issn = {1815-8846},
    doi = {rjbsci.2010.64.67},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2010.64.67},
    author = {Takashi,Kouchi and},
    keywords = {insulin,fragment,²-endorphin,Feed intake,central nervous system,chick},
    abstract = {Recently, researchers found that β-endorphin regulates the activity of the central melanocortin system and its activation provides an inhibitory feedback mechanism in the brain of neonatal chicks. It is known that fragments of β-endorphin have biological activities. Thus, the present study was done to elucidate whether N- or C-terminal of β-endorphin fragment affects the insulin-induced anorexia in chicks. Researchers found that intracerebroventricular injection of insulin with N-terminal fragment, β-endorphin-(1-27), accelerated the insulin-induced hypophagia in neonatal chicks during the 60 min period postinjection. Conversely, the anorexic effect of insulin was attenuated by C-terminal fragment, β-endorphin-(30-31). These data suggest that both fragments involve in the regulation of feeding behavior and they may modulate the activity of the central melanocortin system in the brain of neonatal chicks.}
    }