@article{MAKHILLRJBS20105811144,
    title = {The Hydro-Alcoholic Extract of Pomegranate Seed Has Anti-Inflammatory Effects on Formalin-Induced Inflammation in Rat Hind Paw},
    journal = {Research Journal of Biological Sciences},
    volume = {5},
    number = {8},
    pages = {561-564},
    year = {2010},
    issn = {1815-8846},
    doi = {rjbsci.2010.561.564},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2010.561.564},
    author = {Peyman,Ali Asghar,Ardeshir and},
    keywords = {formalin,rat paw edema,anti-inflammatory,Pomegranate seed,indomethacin,Iran},
    abstract = {Several <I>in vivo</I> studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms. In the present study, the anti-inflammatory properties of total hydro-alcoholic extract isolated from pomegranate seed were investigated in formalin-induced rat paw edema. The studied male Wistar albino rats (n = 30) were divided into 5 groups. Inflammation was created by injection of formalin (2.5%) intraplantarily. Then different doses of extract (100, 200, 400 mg kg<SUP>-1</SUP>) were injected in 3 groups, indomethacin (5 mg kg<SUP>-1</SUP>) was injected in 4th group and control group received 5 mL of normal saline intraperitoneally. About 1-3 h after injection of the extract, indomethacin and saline, the volume of paw was measured in all groups by plethysmometer. The results showed hydro-alcoholic extract of pomegranate seed has dose-dependent anti-inflammatory effect and the highest anti-inflammatory effect was observed in the dose of 400 mg kg<SUP>-1</SUP>.}
    }