@article{MAKHILLRJBS20105111063,
    title = {<I>In vitro</I> Evaluation of Hydroxyl and Nitric Oxide Radical Scavenging Activities of Artemether},
    journal = {Research Journal of Biological Sciences},
    volume = {5},
    number = {1},
    pages = {102-105},
    year = {2010},
    issn = {1815-8846},
    doi = {rjbsci.2010.102.105},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2010.102.105},
    author = {L.,A.,M.,O.,B. and},
    keywords = {in vitro,Artemisinins,pathophysiology,Free radical,reactive oxygen and nitrosative stress,Nigeria},
    abstract = {The hydroxyl and nitric oxide radical scavenging activities and total phenolic content of artemether were investigated <I>in vitro</I>. The concentrations of artemether (200-1000 &#956;g mL<SUP>-1</SUP>) did not exhibit hydroxyl radical scavenging activity except at 200 &#956;g mL<SUP>-1</SUP> concentration. The mean values for the hydroxyl radical scavenging for the different concentration (200, 400, 600, 800 and 1000 &#956;g mL<SUP>-1</SUP>) of artemether were 47.55&plusmn;11.28, -3.49&plusmn;13.16, -30.09&plusmn;6.09, -34.74&plusmn;4.29 and -49.00&plusmn;7.75%, respectively. The total phenolic content of artemether in ethylacetate ranged from 208.00&plusmn;48.33 (SD) to 340.00&plusmn;14.14 &#956;g mL<SUP>-1</SUP>, while the total phenolic content of artemether in methanol ranged from 90.00&plusmn;6.3 (SD) to 122.00&plusmn;35.44 &#956;g mL<SUP>-1</SUP>. Total phenolic content of artemether was significantly higher in ethyl acetate than in methanol at all concentration investigated (p&lt;0.05). The total phenolic content arthemeter was influenced by the organic solvent used as a medium for preparing artemether.}
    }