@article{MAKHILLRJBS20083810685,
    title = {Correlation of Cyclooxygenase 2 (Cox-2) Presentation and Inflammatory Cells Infiltration in Colorectal Cancer: A Histopathological and Immunohistochemical Study},
    journal = {Research Journal of Biological Sciences},
    volume = {3},
    number = {8},
    pages = {916-918},
    year = {2008},
    issn = {1815-8846},
    doi = {rjbsci.2008.916.918},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2008.916.918},
    author = {F. Naghshvar,Z. Torabizadeh,O. Emadian,A. Khalilian,I. Maleki and},
    keywords = {Cerrical spine,traoma,surgical decompression,cancer,inflammatory cells},
    abstract = {Colorectal cancer is the third most common cancer in the world and the second most common cause of cancer related death. Cox-2 has been reported to be significantly increased in up to 85% of human sporadic colorectal carcinoma. Little is known about interaction between Cox-2 and inflammatory cells of colorectal carcinoma. In all cases, archival H and E slides of the primary tumor were retrieved and reviewed to confirm pathological facture and to select suitable tissue blocks for Immunohistochemical analysis. The expression of Cox-2 was positive (grade 3-7) in 71.3% of tumors and associated with neutrophils, eosinophil, mast cell, macrophages and CD3+ lymphocytes (p = 0.001). Correlation of Cox-2 expression and CD8 lymphocytes was not significant (p = 0.569). The main purpose of this study was to evaluate the interaction between the Cox-2 expression and inflammatory cells. We showed that there is a close relationship of Cox-2 expression and mast cells, neutrophils, eosinophils, macrophages, lymphocyte (CD3+). The only exception was CD8 positive lymphocytes.}
    }