@article{MAKHILLRJBS200831110770,
    title = {Plasminogen Activator Inhibitor-1-675 4G/5G and Methylenetetrahydrofolate Reductase Gene Variants in Young Acute Myocardial Infarction and Juvenile Ischemic Stroke},
    journal = {Research Journal of Biological Sciences},
    volume = {3},
    number = {11},
    pages = {1341-1343},
    year = {2008},
    issn = {1815-8846},
    doi = {rjbsci.2008.1341.1343},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2008.1341.1343},
    author = {Giulia Bivona,Chiara Bellia,Salvatore Cammarieri,Bruna Lo Sasso,Rosachiara Carollo,Rosalinda Raineri,Gaia Chiarello,Antonietta Caruso and},
    keywords = {Thrombophilia,stroke,myocardial infarction,gene variants,plasminogen},
    abstract = {Cardiovascular diseases often recognize a hereditary-familial genetic risk patterns and a substantial proportion of variability in clinical features of atherosclerosis could probably be explained by genetic factors. Aim of this study is to compare prevalence of factor V Leiden, factor II 20210A, PAI-1-675 4G/5G and MTHFR C677T gene variants in 2 cardiovascular disease clinical features: young acute myocardial infarction (<50 years) and ischemic stroke. Plasminogen Activator Inhibitor-1-675 4G/5G didn’t show significant difference between patients and controls while, between patient groups, the polymorphism was most present in myocardial infarction group than in juvenile stroke. Polymorphisms in Homocysteine metabolism: MTHFR C677T variants was significantly higher in patients with myocardial infarction compared with those affected by ischemic Stroke.}
    }