@article{MAKHILLRJBS20072610456,
    title = {Macrolides Antibiotics in Odontostomatological Practice: Past, Present and Future},
    journal = {Research Journal of Biological Sciences},
    volume = {2},
    number = {6},
    pages = {643-649},
    year = {2007},
    issn = {1815-8846},
    doi = {rjbsci.2007.643.649},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2007.643.649},
    author = {G.A. Scardina,A. Ruggieri,F. Carini,V. Valenza and},
    keywords = {Antibiotics,macrolides,efflux pumps,bacterial resistance,multidrug resistance,ketolides,telithromycin},
    abstract = {Macrolides are considered the second choice in the odontostomatological practice especially in case of allergic reactions to the most important and well-known group of a-lactams. This group of antibiotics are more diffused in the daily practice of dentistry but during the time macrolides have shown a big potential in constant increasing. In this study, we report a review of the major features of these antibiotics which have become in the time farmacological choice effective and reliable versus bacterial infections supported by a-hemolytic streptococci, pneumococci, staphylococci, enterococci, mycoplasma, mycobacteria, some rickettsia and chlamydia. Furthermore, we refer about the recent researches that show the anti-inflammatory potentiality of the macrolides and the recent discoveries on the new pharmacological targets to exceed the problem of the bacterial resistance: the efflux pumps. Finally, we expose about a new class of antibiotic derived directly by the macrolides: Ketolides. They represent the future of the macrolides.}
    }