@article{MAKHILLIJMMAS20191528608,
    title = {A Review on RNA-Interference, Non-Coding-RNA, Micro-RNA, Gene Regulation and Gene
Doping},
    journal = {International Journal of Molecular Medicine and Advance Sciences},
    volume = {15},
    number = {2},
    pages = {5-13},
    year = {2019},
    issn = {1813-176x},
    doi = {ijmmas.2019.5.13},
    url = {https://makhillpublications.co/view-article.php?issn=1813-176x&doi=ijmmas.2019.5.13},
    author = {Alemayehu},
    keywords = {Doping,genes,interference,MicroRNA,non-coding RN},
    abstract = {Many physiological activities take place in the
cells of living organisms. These cellular activities are
controlled by the genes of the cell. The activities of DNA,
RNA and proteins are indispensable for living things.
However, the importance of RNA has long been in the
shadow of other cellular components, DNA and proteins.
Later as the time progress on, this was experimentally
demonstrated revealing that during gene expression, DNA
is copied in a molecule of messenger RNA (mRNA) that
is then translated into proteins molecules. Ribonucleic
acid (RNA) is classified in to different categories based
on their functions and sizes. Therefore, objectives this
review is: to understand the mechanism how RNA
interferes, how non-coding RNA regulates gene
expression, to understand concept of gene doping and
related effects and to understand MicroRNAs and their
role for viral diagnosis. The term non-coding RNA
(ncRNA) is commonly employed for RNA that does not
encode a protein. Cells of living things are self-regulated
by the means of interactions between different molecules.
RNAs with regulatory function in most cases by base
pairing with complementary sequences in other RNAs or
DNA, forming RNA: RNA and probably RNA: DNA
complexes that are recognized and acted upon by a
relatively generic infrastructure (such as RNA-induced
silencing complex (RISC) complexes or RNA editing
enzymes). On the other hand, RNA interference (RNAi)
is a form of Post-Transcriptional Gene Silencing (PTGS)
which is regarded as a mechanistic variant of RNAi.
MicroRNAs are a group of small, non-coding RNAs
which regulate the process of gene expression in a
sequence-specific manner. MicroRNAs plays a role in
disease diagnosis due to their effort in apoptosis,
proliferation of cell, differentiation and development. In
generally sense, gene doping is could be defined as “the
use of genes, genetic elements and/or cells that have the
capacity to enhance athletic performance for
non-therapeutic purposes.”}
    }