@article{MAKHILLIJMMAS2010638592,
    title = {Susceptibility Faecal Isolates of Commensal <I>E. coli </I>from Cattle to Fluoroquinolones and Cephalosporins},
    journal = {International Journal of Molecular Medicine and Advance Sciences},
    volume = {6},
    number = {3},
    pages = {43-48},
    year = {2010},
    issn = {1813-176x},
    doi = {ijmmas.2010.43.48},
    url = {https://makhillpublications.co/view-article.php?issn=1813-176x&doi=ijmmas.2010.43.48},
    author = {A.O.,O.,O.A. and},
    keywords = {Cephalosporins,animal medicine,regulated plasmids,spectrum,beta-lactamase,Nigeria},
    abstract = {About 500 isolates of <I>Escherichia coli </I>were recovered from apparently healthy cattle and tested for their susceptibility to third generation cephalosporins and extended spectrum beta-lactamase producers were detected using the double dusk synergy test. Representative isolates were selected on the basis of their cephalosporin resistance patterns for plasmids analysis and mating experiment using <I>E. coli </I>25922 as recipient. Resistance to cefoxitin was highest as 395 (79.0%) showed resistance to the antibiotic while resistance to ceftriaxone was the lowest with 87 (17.4%) isolates. Seventy two isolates were confirmed to be extended spectrum beta-lactamase producers. Two of 13 representative isolates selected among the extended spectrum beta lactamase producers carried single plasmids while the remaining 11 isolates contain multiple plasmids ranging from 1.2-22.2 kb. The cephalosporin-resistant isolates also carried plasmids with sizes ranging from 4.32-32 kb. Twelve isolates among the extended spectrum beta-lactamase producers that carried plasmids successfully transferred the plasmids to the recipient while all the cephalosporin-resistant isolates successful transferred plasmids to the recipient strain. The use of third-generation cephalosporins in animal medicine should be regulated.}
    }