@article{MAKHILLIJMMAS2009518581,
    title = {Contextual Developmental History of Evolving Global and Focal Parameters in Multiple Sclerosis Progression},
    journal = {International Journal of Molecular Medicine and Advance Sciences},
    volume = {5},
    number = {1},
    pages = {1-5},
    year = {2009},
    issn = {1813-176x},
    doi = {ijmmas.2009.1.5},
    url = {https://makhillpublications.co/view-article.php?issn=1813-176x&doi=ijmmas.2009.1.5},
    author = {Lawrence M.},
    keywords = {Inflammation,multiple sclerosis,plaque,demyelination,blood-brain barrier},
    abstract = {Dimensional confines of the individual demyelinating plaque in multiple sclerosis indicate a focal or multifocal involvement of the parent axon and also a global progressiveness of the involvement of the blood-brain barrier. A gliopathy affecting viability of the astrocytic foot processes may be re-interpreted within constructs of involvement by a depleted oligodendroglial cell compartment within the demyelinating plaque. It is particularly significant to view dynamics of remyelination within a contextual setting of an afflicted parent axon. Progressiveness is hence compounded by multiple constructs in development of a lesion that is physico-chemically related to new foci of involvement of grey and white matter, beyond the confines of established plaque pathology. In this sense, therefore, a conventional role for a presumed viral etiology would insufficiently account for a multi-focal involvement that mirrors the global dimensions of the blood-brain barrier defects.}
    }