@article{MAKHILLIJMMAS2005128482,
    title = {Paraneoplasia as an Epigenetic Reflection of Systemic Dimensions of Potential Neoplastic Spread},
    journal = {International Journal of Molecular Medicine and Advance Sciences},
    volume = {1},
    number = {2},
    pages = {130-136},
    year = {2005},
    issn = {1813-176x},
    doi = {ijmmas.2005.130.136},
    url = {https://makhillpublications.co/view-article.php?issn=1813-176x&doi=ijmmas.2005.130.136},
    author = {M. Lawrence and},
    keywords = {Potential,neoplastic,spread,paraneoplasia,epigenetic reflection,systemic,evolution},
    abstract = {Paraneoplasia as an essential system of involvement inherent to genetic attributes of neoplastic cellular proliferative events might actually involve an epigenetic process in a context of, however, systemic progression by the neoplasm. Indeed, a strict referential series of events as steps in systemic involvement of the patient by a proliferating and infiltrative neoplasm might simply constitute modes of how such a neoplasm
is, itself, a primarily systemic phenomenon with paradoxically focal manifestations that implicate however, progressive regional spread. In this sense, neoplasia might primarily constitute a process of systemic dimensions that is manifested also as a systemic phenomenon of paraneoplasia. In addition, one might speak of paraneoplastic syndromes as, for example, myasthenia gravis or endocrine manifestations, that parallel an associated neoplasm as a focal lesion of systemic dimensions. Indeed, genetic and epigenetic manifestations of neoplasia would involve different aspects of a phenomenon of systemic evolution that is not only manifested focally or regionally but is progressive mainly in terms of a focality that evolves in a strictly systemic context of genesis and epigenesis.}
    }