@article{MAKHILLTC2014918454,
    title = {Dental Tissue-Derived Stem Cells Exerts Therapeutic Effects on Chronic Myocardial Infarction Model of Rabbit},
    journal = {The Cardiology},
    volume = {9},
    number = {1},
    pages = {1-6},
    year = {2014},
    issn = {1811-8194},
    doi = {tcard.2014.1.6},
    url = {https://makhillpublications.co/view-article.php?issn=1811-8194&doi=tcard.2014.1.6},
    author = {Soontaree,Nakrob,Ratikorn,Petcharin and},
    keywords = {Mesenchymal stem cells,myocardial infarction,cardiac repair,therapeutic,dental tissue},
    abstract = {Coronary artery disease is a common precursor to sudden cardiac 
  death worldwide. Advanced symptoms usually include Myocardial Infarction (MI) 
  due to atherosclerosis of coronary arteries. To repair or regenerate lost myocardium 
  and coronary vasculature, stem cell transplantation is a promising therapeutic 
  approach for the treatment of coronary heart diseases. In this study, the therapeutic 
  effects of multipotent Stem Cells from Human Exfoliated Deciduous teeth (SHED) 
  were examined. The 30 adult male New Zealand White rabbits underwent a left 
  thoracotomy approach for producing chronic infarcted heart. The marginal branch 
  of the left circumflex coronary artery was ligated over 8 weeks to produce an 
  ischemic area of 20-25% of the Left Ventricle (LV). SHEDs were freshly prepared 
  and 1.0 mL of 10<SUP>6</SUP> cells were injected to each of eight rabbits via 
  the marginal ear vein. Echocardiography and Heart Rate Variability (HRV) were 
  measured to reflect cardiac function. The infarcted size measurements were performed 
  at the end of each experiment. The SHED treatment groups show significant improvement 
  in cardiac autonomic tone and reduction in infarcted size. Dental tissue derived 
  stem cell transplantation confirmed a restoration of the heart. The results 
  suggest that SHED could provide an alternative selection of the precursor cells 
  for cardiac repair.}
    }