@article{MAKHILLJAVA20201964623,
    title = {Responses of Male Albino Rats under Stress of Mixed Pyrethroids},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {19},
    number = {6},
    pages = {75-81},
    year = {2020},
    issn = {1680-5593},
    doi = {javaa.2020.75.81},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2020.75.81},
    author = {B.S.,O.A.,K.O. and},
    keywords = {Stress,inhalation,haemogram,lipids,electrolytes,pyrethroid},
    abstract = {The toxicity of mixed pyrethroids insecticides
to mammalian animals has received much attention in
recent years because animals exposed to these insecticides
exhibited changes in their physiological, haematological
and biochemical activities beside other pathological
features. The study aimed to investigate the responses of
male albino rats under stress of inhalational exposure to
mixed pyrethroids on the haemogram, lipids, electrolytes,
liver and kidney functional indices. Twenty male rats
were maintained on standard healthy laboratory
conditions and had free access to food and drinking water
ad libitum. The rats were divided into four equal groups
A-D. The group A represented the healthy control rats,
while groups B, C and D were inhalationaly exposed to
mixed pyrethroids at doses of 30, 60 and 90 mg kg<sup>&#150;1</sup>
respectively for 2 weeks. At the end of the exposure,
blood sample was collected for haematological studies
while serum was used for biochemical analysis. There
was significant reduction in PCV, MCV, MCH and
MCHC compared to the healthy control group while total
leucocytes counts was significantly elevated. There was
also significant increase in the activities of ALT, AST as
well as marked hypoproteinaemia, hypoalbuminaemia
and azotaemia indicating liver and kidney dysfunction.
However, the lipids and the electrolytes were equally
perturbed. It was concluded that exposure to mixed
pyrethroids predisposes the male rats to stress, altered
haemogram with varying disturbances of various
biochemical parameters resulting in death of rats exposed
to highest dose of the mixed pyrethroids.}
    }