@article{MAKHILLJAVA201413164421,
    title = {Effect of <I>Lactobacillus delbrueckii</I> on Jejunum Innate Immune-Related Gene Expression in Mice},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {13},
    number = {16},
    pages = {989-997},
    year = {2014},
    issn = {1680-5593},
    doi = {javaa.2014.989.997},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2014.989.997},
    author = {Tie-Jun,Jie-Lin,Shao-Ping,Guan,Jie,Wen-Kai,Jian-Wen,Yu,Feng-Ming and},
    keywords = {Lactobacillus delbrueckii,jejunum,peneth cell,innate immune,CRS-1C},
    abstract = {Probiotics, regarded as live microorganisms, play important 
  roles in regulating intestinal inflammatory responses and innate immunity. Although, 
  intestinal immunmodulation of probiotics have been enormously conducted into 
  data, the effects of <I>Lact. delbrueckii</I> on jejunum innate immunity are 
  rarely reported. This study aimed to investigate the effects of <I>Lact. delbrueckii</I> 
  on serum profiles, jejunum inflammatory cytokines and innate immune-related 
  genes expression in mouse. A total of 32 Kunming male mice were randomly divided 
  into four groups and each group were orally administrated with saline normal, 
  living <I>Lact. delbrueckii</I>, heat-killed <I>Lact. delbrueckii</I> and Spent 
  Culture Supernatant (SCS). Serum profiles (IL-2, IgG) and jejunum immune-related 
  gene expression were detected including inflammatory cytokines (INF-&#947;, 
  TNF-&#945;, IL-17, IL-13) peneth cell-sepcific gene (cryptdin 1, 4, 5, lysozyme 
  C, CRS-1C, CRS-4C and sPLA2) and goblet cell-specific gene (mucin-2 and mucin-4). 
  Compared with control group, orally administrated SCS significantly decreased 
  (p&lt;0.05) ADG of mice. Orally administrated living and heat-killed <I>Lact. 
  delbrueckii</I> group significantly increased (p&lt;0.05) serum IL-2 level and 
  while SCS remarkably decreased (p&lt;0.05) serum IgG level. Meanwhile, oral 
  administration of living <I>Lact. delbrueckii</I> significantly enhanced (p&lt;0.05) 
  jejunum inflammatory cytokines (INF-&#947;, TNF-&#945;, IL-17) expression. SCS 
  significantly increased (p&lt;0.05) peneth cell-sepcific gene (cryptdin 1, 4, 
  5 and sPLA2) gene expression. In conclusion, oral administration of <I>Lact. 
  delbrueckii</I> affects serum profiles and jejunum innate immune-related gene 
  expression and thereby modulates jejunum innate immunity.}
    }