@article{MAKHILLJAVA201413154408,
    title = {The Differences of Serum IFN-β and Antibodies Concentrations in Chickens at Early and Late ALV-J Infection Stage},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {13},
    number = {15},
    pages = {930-936},
    year = {2014},
    issn = {1680-5593},
    doi = {javaa.2014.930.936},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2014.930.936},
    author = {Yan,Yue,Xi,Kai,Tian-Jie,Qing,Yi-Ping,Xiao-Ling,Hua-Dong and},
    keywords = {ALV-J,IFN-B,immunoglobulin,ALV-J infection stage,chicken},
    abstract = {Interferon-β (IFN-β) and immunoglobulin M (IgM), 
  immunoglobulin G (IgG) are essential in anti-retrovirus progress. ALV-J is a 
  kind of ubiquitous retrovirus in chicken. To investigate whether natural Avian 
  Leukosis Virus strain J (ALV-J) infection has effect on the concentrations of 
  serum IFN-β, IgM and IgG, two important time points after hatching, 3 and 
  18 weeks age which represent the early and late stages of ALV-J infection, respectively 
  were decided to study. The results reveal that the serum IFN-β, IgM and 
  IgG increase at the early stage of ALV-J infection while decrease at the late 
  stage compared with the control chickens which indicate that ALV-J infection 
  boosts the immune response and up-regulates IFN-β and antibody while long-term 
  infection suppresses immune function and down-regulates IFN-β and antibody.}
    }