@article{MAKHILLJAVA20131284112,
    title = {Serum mRNA Levels of Interleukin-1α and Interleukin-1β Increase upon Exposure to Intermittent Hypoxia},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {12},
    number = {8},
    pages = {888-891},
    year = {2013},
    issn = {1680-5593},
    doi = {javaa.2013.888.891},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2013.888.891},
    author = {Hyun-Soo and},
    keywords = {Intermittent hypoxia,serum,interleukin-1a,interleukin-1B,rat},
    abstract = {Intermittent Hypoxia (IH) is the most common pattern of hypoxic 
  exposure. The pro-inflammatory cytokine Interleukin (IL)-1 is present in the 
  tissues or systemic circulation in many inflammatory conditions. Although, some 
  earlier studies have shown that hypoxia enhanced the production of pro-inflammatory 
  cytokines, the effects of IH on the expression of <I>IL-1</I> gene have not 
  been investigated yet. The aim of this study was to examine whether IH affects 
  the mRNA expression levels of two IL-1 molecules, IL-1&#945; and IL-1&#946; 
  in rat serum. To obtain IH, 11 male Sprague-Dawley rats were placed in a hypobaric 
  chamber (282 mm Hg, 30 min day<SUP>-1</SUP>, 14 days). The mRNA expression levels 
  of IL-1&#945; and IL-1&#946; in serum were determined using quantitative real-time 
  RT-PCR. All of the rats exposed to IH exhibited significantly higher levels 
  of IL-1 mRNA expression than the normoxic control rats. Exposure to IH resulted 
  in 6.0 and 6.3 fold increases in the amount of IL-1&#945; and IL-1&#946; mRNA 
  when compared to that of the control group (p&lt;0.001, both). Researchers demonstrated 
  that the serum levels of IL-1&#945; and IL-1&#946; mRNA were significantly increased 
  in rats following 14 days of exposure to IH. The result suggests that IH has 
  a positive effect on transcription of the <I>IL-1&#945;</I> and <I>IL-1&#946;</I> 
  genes.}
    }