@article{MAKHILLJAVA20131213976,
    title = {Analysis of Synonymous Codon Usage in Dengue Viruses},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {12},
    number = {1},
    pages = {88-98},
    year = {2013},
    issn = {1680-5593},
    doi = {javaa.2013.88.98},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2013.88.98},
    author = {Yong-Sheng,Jun-Jun,Feng,Jie,Jian-Hua,Li-Na,Yao-Zhong,Hao-Tai and},
    keywords = {Dengue virus,relative synonymous codon usage,effective number of codons,significant factor,codon usage pattern,codon usage bias,mutation pressure},
    abstract = {Dengue Viruses (DENV) are the most common arboviral pathogens 
  in tropical and subtropical regions of the world. Analysis of codon usage patterns 
  of DENV can reveal much about the molecular evolution of the viruses. The codon 
  usage patterns of 119 samples of DENV were analysed including the Relative Synonymous 
  Codon Usage (RSCU) and Codon Usage Bias (CUB). The overall extent of codon usage 
  bias is low in DENV. The codon usage patterns of the 4 serotypes of DENV are 
  significant different indicating that the evolutionary genetics of them are 
  independent. Compositional constraint is a significant factor that affects codon 
  usage variation. Mutation pressure is the main factor in codon usage variation 
  of these viruses. Furthermore, natural selection may play a role in codon usage 
  pattern of DENV as well. However, more comprehensive analysis is needed for 
  show the deeper characteristic of synonymous codon usage and other responsible 
  factors of codon usage bias in DENV.}
    }