@article{MAKHILLJAVA20131234018,
    title = {Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both <I>in vitro</I> and <I>in vivo</I>},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {12},
    number = {3},
    pages = {352-359},
    year = {2013},
    issn = {1680-5593},
    doi = {javaa.2013.352.359},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2013.352.359},
    author = {Jianzhen,Zijie,Li,Hai-Lian,Yuande,Chunyang,Jiagang,Yi-Wang and},
    keywords = {Mangiferin,cdc2-cyclinB1 singling pathway,PKC-NFkB pathway,drugs,tumor},
    abstract = {Mangiferin, a C-glucosylxanthone (1, 3, 6, 7-tetrahydroxyxanthone-C2-&#946;-D-glucoside) purified from plant sources was shown to have <I>in vitro</I> growth-inhibitory and apoptosis-inducing activity against MCF-7 cells and it also possessed anti-tumor property on MCF-7 xenograft mice <I>in vivo</I>. Mangiferin triggered G<SUB>2</SUB>/M phase cell-cycle arrest via down-regulating cdc2-cyclinB1 singling pathway and induced apoptotic cell death through inhibiting PKC-NF&#954;B pathway in human breast carcinoma MCF-7 cells. In addition, mangiferin had anti-cancer effects <I>in vivo</I> and it could decrease the volume and weight of subcutaneous tumor mass obviously as well as expanded lifespan of xenograft mice. With the molecular mechanisms of mangiferin-induced anti-tumor activities were gradually clarified, traditional Chinese medicine would become potential anti-neoplastic drugs in future cancer therapeutics.}
    }