@article{MAKHILLJAVA20131224000,
    title = {Identification of Polymorphisms in the Bovine Paraoxonase 1 Gene},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {12},
    number = {2},
    pages = {229-233},
    year = {2013},
    issn = {1680-5593},
    doi = {javaa.2013.229.233},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2013.229.233},
    author = {Jianping,Juan,Shengguo,Zhaoming,Xinrong and},
    keywords = {Cattle,PON1 gene,exon,polymorphism,PCR-SSCP,China},
    abstract = {The Paraoxonase 1 gene (<I>PON1</I>) encodes paraoxonase which 
  hydrolyzes organophosphate pesticides and nerve gasses. In addition, PON1 has 
  been shown to have significant antiatherosclerotic effects and is a major candidate 
  gene associated with the reduction of atherosclerosis. Most of the literature 
  reporting polymorphisms in PON1 has been in humans while less information about 
  the polymorphism of <I>PON1</I> gene has been reported in mammals, especially 
  in bovine species. Polymorphisms in the <I>PON1</I> gene were evaluated in Simmental 
  x Chinese Yellow cattle (n = 32) and Longdong cattle (n = 37) using PCR-SSCP 
  in exons 1-9 of the <I>PON1</I> gene. Results demonstrated polymorphisms in 
  the bovine <I>PON1</I> gene at exons 4, 6, 8 and 9. DNA sequencing identified 
  specific substitutions in exon 4, 6, 8 and 9 (g.338G&gt;A, g.647C&gt;T, g.896C&gt;T 
  and g.998T&gt;C, respectively). Two genotypes were identified in exon 4 (GG 
  and AG), exon 6 (TT and CT) and exon 9 (TT and CT) while 3 genotypes were identified 
  in exon 8 (CC, CT and TT). The allelic frequency for the G allele was 92.03% 
  and the A allele was 7.97% in exon 4. Allelic frequencies for the T and C alleles 
  were 89.86 and 10.14%, respectively, in exon 6. In exon 8, frequencies for the 
  C and T alleles were 94.93 and 5.07%, respectively. In exon 9, allelic frequencies 
  for the T and C alleles were 88.41 and 11.59%, respectively.}
    }