@article{MAKHILLJAVA20121173318,
    title = {Tachyplesin I Induce Drug Resistance in Bacteria <I>in vitro</I>},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {7},
    pages = {939-945},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.939.945},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.939.945},
    author = {W.T.,J.,J.G.,G.,Zh.L.,L.J.,J. Zh. and},
    keywords = {Antimicrobial peptides,resistance,tachyplesin I,Escherichia coli,Staphylococcus aureus,China},
    abstract = {Tachyplesin I is a 17 amino acid cationic antibacterial peptide with a typical cyclic antiparallel &#946;-sheet structure. It is not clear whether tachyplesin I can induce resistance in bacteria. Therefore, two selection procedures by gradually increasing the induction concentration of tachyplesin I were performed to determine whether tachyplesin I could induce resistance in <I>Escherichia coli</I> and <I>Staphylococcus aureus in vitro</I>. The results showed that tachyplesin I did not induce resistance in <I>Escherichia coli</I> ATCC25922, F41 and <I>Staphylococcus aureus </I>ATCC25923 in this study whereas high resistance to benzylpenicillin was induced using the same procedures in <I>Staphylococcus aureus</I> ATCC25923. Furthermore, no cross-resistance between tachyplesin I and benzylpenicillin was observed. It is suggested that tachyplesin I may be a safe antibacterial agent for future use in clinical practice.}
    }