@article{MAKHILLJAVA20121163274,
    title = {Relationship Between Fluoroquinolone Resistance and <I>gyrA</I>, <I>parC</I> Gene in <I>Streptococcus suis</I> Type 2 Isolates in Hebei Province China},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {6},
    pages = {719-722},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.719.722},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.719.722},
    author = {Zengjun Ma,Ping,QiuYue Wang,Hai Fang,JianHua Wu,ZhiXin Fu,Qing Hui Jia and},
    keywords = {Streptococcus suis,fluoroquinolone,parC gene,gyrA gene,amino acid,China},
    abstract = {To detect the relationship between fluoroquinolone resistance and <I>gyrA</I>, <I>parC</I> gene mutation in <I>Streptococcus suis</I> type 2. The MIC of 14 strains of <I>Streptococcus suis</I> type 2 were determined by microdilution. The genes encoding the Quinolone-Resistance Determining Region (QRDRs) of parC and gyrA in fluoroquinolone-susceptible and resistant <I>Streptococcus suis</I> clinical isolates were identified and sequenced. Ser to Phe and Arg to Leu mutation at position 79 and 87 of the <I>parC</I> gene was detected in fluoroquinolone resistance SS2 and Arg to Ser or Ser to Arg mutations at the position 66 or 81 of <I>gyrA</I> gene were detected in 2 highly resistance strains; no amino acid changes in gyrA or parC were detected for 7 fluoroquinolone-susceptible strains; the mutations in both genes were found in the strains with MIC of fluoroquinolone &gt;32 &#956;g mL<SUP>-1</SUP>. Mutations in <I>parC</I> gene may result in low level resistance against fluoroquinolone and mutations in both <I>gyrA</I> and <I>parC</I> genes result in high level resistance.}
    }