@article{MAKHILLJAVA201211223860,
    title = {Induced Protection against Challenged <I>Schistosoma mansoni</I> Infection in Mice Immunized with Soluble Egg Antigen},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {22},
    pages = {4127-4134},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.4127.4134},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.4127.4134},
    author = {Magda,Jamila and},
    keywords = {Schistosoma mansoni,soluble egg antigen,vaccine-lung,histopathology,immunohistochemistry,Saudi Arabia},
    abstract = {Schistosomiasis is a parasitic disease causing serious chronic 
  morbidity in tropical countries. Even though an effective treatment exists, 
  it does not prevent re-infection and the development of an effective vaccine 
  still remains the most desirable means of control for this disease. The possible 
  applicability of immunization with a partially purified Soluble Egg Antigen 
  (SEA, 100-137 kDa) for protection against <I>Schistosoma mansoni</I> infection 
  in challenged mice was evaluated by histological and immunohistochemical studying 
  of schistosomula-associated inflammatory reactions and deposition of schistosomal 
  antigens in lung tissues. Schistosomula and inflammatory foci were counted in 
  lung sections by histologic scoring for 25 days Post-Infection (PI). In control 
  non-immunized mice, schistosomula number reached its peak earlier (day 7), decreased 
  rapidly and worms were barely detectable on day 25. In immunized mice, the number 
  reached its peak later (day 9), decreased gradually and many worms were still 
  retained in the lungs until day 25. Mild pulmonary cellular reaction was noticed 
  in control mice while in immunized ones, evident mononuclear cellular infiltration 
  with inflammatory foci appeared earlier (day 7) and significantly increased 
  on subsequent days and was most probably of Delayed Type Hypersensitivity (DTH). 
  Schistosomal antigen deposition in lung tissues was markedly augmented in immunized 
  mice. The present study indicates that immunization with this SEA caused augmentative 
  pulmonary response against challenge infection, represented by inducing anamnestic 
  inflammation in lung tissues with consequent blocking of migration of lung schistosomula 
  and more deposition of schistosomal antigens with more stimulation of the immune 
  response. So, this type of antigen may be useful for the composition of a vaccine 
  against schistosomiasis.}
    }