@article{MAKHILLJAVA201211183718,
    title = {Antibacterial Activity and Mechanism of <I>Pogostemon cablin</I> Against Bacteria from Milk of Dairy Cows Suffering with Mastitis},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {18},
    pages = {3289-3297},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.3289.3297},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.3289.3297},
    author = {Cheng,Min,Feng and},
    keywords = {Pogostemon cablin,essential oil,bovine mastitis,in vitro and in vivo antibacterial activity,antibacterial mechanism,China},
    abstract = {Minimum Inhibitory Concentrations (MICs) of 3 extracts and oil from <I>Pogostemon cablin </I>against isolates from milk produced by dairy cow with mastitis were determined by Agar Dilution Method. Water extract had low activity; ethanol extract and ethanol-water extract had moderate effects having MICs ranging from 25.0-100.0, 12.5-100.0 mg mL<SUP>-1</SUP>, respectively. Oil had strong activity against Gram-positive and Gram-negative isolates with MICs ranging from 0.2-8.2 mg mL<SUP>-1</SUP>. Oil also, showed strong efficacy in mouse peritonitis model infected with <I>S. aureus</I> or <I>E. coli</I>. Their actions were dose-dependent. Obvious morphological changes were observed by TEM in oil-treated <I>E. coli</I> or <I>S. aureus</I> such as a remarkable electron-light region small electron-dense granules disturbed cytoplasmic membrane and abnormal cell division. In conclusion, antibacterial substance of <I>P. cablin</I> was oil which had broad-spectrum antibacterial activities so to make it a potential candidate as antibacterial agent to treat bovine mastitis.}
    }