@article{MAKHILLJAVA201211163647,
    title = {Correlated Responses to Bi-Directional Selection for Sheep Red Blood Cell Titer in White Leghorns},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {16},
    pages = {2879-2884},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.2879.2884},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.2879.2884},
    author = {Qing,Yao-Dong,Jie,Mai-Qing,Ran-Ran,Ji-Lan and},
    keywords = {Immunology chicken,SRBC,selection,disease resistance,reproductive traits},
    abstract = {Four generations of bi-directional selection for antibody response to challenge with SRBC on days 56 were completed in White Leghorn chickens. The anti-SRBC titer and other immune traits were measured in up-selected (H), down-selected (L) and Control (C) lines in each Generation (G0-G4) and reproductive traits were measured in G4. In the 4th generation, the difference in SRBC titers (measured on days 61) between the selected lines was 7.18 versus 6.10, a 17% increase in the H compared to the L lines. The heritability of SRBC titer was 0.26. The genetic correlations between anti-SRBC and IgG (0.87) and IgM (0.81) were high and those between SRBC titers and those against AI (0.56), ND (0.48) and the H/L ratio (0.58) were moderate. Immune and reproductive traits compared among the H, L and C lines in the final Generation (G4) showed that AI, ND and IgM were improved significantly (p<0.05) by selection for SRBC but the age at first lay was slightly delayed (0.48 days) in the H line. This study demonstrates that selecting for antibody response to SRBC improves other immune traits consistent with broad disease resistance of chickens.}
    }