@article{MAKHILLJAVA201211153604,
    title = {Geometrical Study on FMDV Genome Based on Z-Curve},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {15},
    pages = {2630-2640},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.2630.2640},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.2630.2640},
    author = {Yong-Lu,Hua,Xin-Sheng,Yu-Zhen,Li,Zong-Wang,Peng,Jian-Liang,Shou-Tian and},
    keywords = {homology analysis,mutation,FMDV,geometrical study,Z-curve,China},
    abstract = {The Z-curve is a geometrical tool for visualizing and comparing 
  genomes. Since, the curve contains the information carried by the given sequence, 
  DNA sequences could be analyzed systematically. In this study, the Foot and 
  Mouth Disease Virus (FMDV) was analyzed by the Z-curve Method. This research 
  concludes that all serotypes FMDV have a close consanguinity but each has its 
  own characteristic by contrast, the three South African serotypes have a much 
  closer affinity. FMDV have three A + T-rich regions and two G + C-rich regions. 
  The most variable regions of FMDV lie in protein coding areas. And the non-coding 
  region is very conservative. O serotype FMDV is most variable compared with 
  A and Asia1 serotype. Those O serotype FMDV in buffalo and goat have a mutation 
  trend. Compared with host, geographic location have a grater influence on FMDV 
  mutation. The A serotype FMDV strains occurred in India after 2002 are more 
  stable and have a closer phylogenetic relationships compared with the Asia1 
  strains which were prevalent before 2002. In general, Z-curve Method shows a 
  widely application prospect in the areas of life sciences. Such as gene sequence, 
  molecular epidemiology, homology, evolution, phylogenetic relationships and 
  genetic diversity analysis.}
    }