@article{MAKHILLJAVA201211153602,
    title = {Protective Effects of Vitamin E and Vitamin C on Gentamicin-Induced Nephrotoxicity in Sheep},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {15},
    pages = {2618-2622},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.2618.2622},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.2618.2622},
    author = {Mohammad and},
    keywords = {Vitamin E and C,gentamicin,nephrotoxicity,sheep,antioxidant vitamins,Iran},
    abstract = {Gentamicin is a commonly used antibiotic medication and this 
  is an aminoglycoside antibiotic, used to treat many types of bacterial infections, 
  particularly those caused by gram-negative organisms. Gentamicin can also be 
  highly nephrotoxic, particularly if multiple doses accumulate over a course 
  of treatment or in dehydrated cases. The aim of this study was to investigate 
  the protective role of vitamin E against Gentamicin-induced nephrotoxicity in 
  sheep. Eighteen healthy Ghezel sheep were randomly divided into three groups 
  of control and treatments with vitamin C and E. All sheep of two groups were 
  received 20 mg/kg/body wt. of Gentamicin every 8 h by intramuscular injection 
  for 10 days. Treatment group were also receive 250 mg/kg/body wt. of vitamin 
  E and C daily by intramuscular injection for 14 days. This study revealed that 
  the GM-induced renal toxicity as measured by multiple functional, structural 
  and enzymatic factors is significantly reduced by co-supplementation of vitamins 
  C and E. The results of this study suggest the potential of antioxidant vitamins 
  to protect against GM-induced nephrotoxicity.}
    }