@article{MAKHILLJAVA201211143598,
    title = {Effects of <I>Androctonus crassicauda</I> Scorpion Venom on the Heart Tissue},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {14},
    pages = {2594-2599},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.2594.2599},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.2594.2599},
    author = {Fatih,Ozcan,Mehmet and},
    keywords = {Scorpion,Androctonus crassicauda,venom,heart,cardiac troponin I},
    abstract = {The aim of this research was to determine the presence of cardiac injury in rabbit animal model with envenomed <I>Androctonus crassicauda</I> venom by serial measurements of cardiac troponin I and assessed the histopathologic changes of the heart for evaluation of the extent of damages. Experimental envenomations were performed by intravenous of 0.5 mL of PSS containing a scorpion venom. Blood samples were collected from each animal (0 min [control]) before envenomation. Blood samples were collected from each animal on the 1st, 3rd, 6th and 24th h after venom injection. Serum cardiac troponin I level determined using abbot architect troponin I kit (Abbott Laboratories, USA). Cardiac tissues taken from envenomed animals were for histopathological examination after 24 h. The scorpion venom led to significantly increased in serum cardiac troponin I enzyme activities at the 3rd, 6th and 24th h after injection when compared with those of the control group. <I>In vivo</I> effects of the venom observed such as salivation, lacrimation, deep dyspnea and tachypnea in rabbits. Histopathological examination of heart tissue was showed development of myocardial injury. This study demonstrated that <I>Androctonus crassicauda</I> venom may be cause development of myocardial injury. The using of cardiac troponin I as a follow-up criterion in the scorpion envenoming may be allow early establishing of the cardiac involvement.}
    }