@article{MAKHILLJAVA201211123494,
    title = {Toxicokinetics of T-2 Toxin, HT-2 Toxin and T-2 Triol after Intravenously Administrated T-2 Toxin in Swine},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {12},
    pages = {1977-1981},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.1977.1981},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.1977.1981},
    author = {Yong-Xue,Hai-Yan,Yu-Jing,Zhen-Qing and},
    keywords = {Toxicokinetics,T-2 toxin,metabolites,swine,blood,parameters},
    abstract = {Toxicokinetics of trichothecene mycotoxin, T-2 toxin, HT-2 toxin and T-2 triol were determined in seven swine, after intravenous administration (i.v.) of T-2 toxin (0.5 mg kg<SUP>-1</SUP>). The T-2 toxin, HT-2 toxin and T-2 triol plasma concentrations were analyzed by HLPC-MS/MS from 2.5 min to 6 h. The mean pharmacokinetic parameters for T-2 toxin, HT-2 toxin and T-2 triol were respectively: half-life (t<SUB>1/2&#955;Z</SUB>) 11.7, 37.7 and 25.6 min; areas under the plasma concentration-time curves (AUC<SUB>0-00</SUB>): 16499, 4619 and 11011 min ng mL<SUP>-1</SUP>. Following i.v administration, times to observed maximal concentration (Tmax) were 2.5, 2.5 and 7.5 min, respectively. No T-2 tetraol was detected at all sampling times. The total body Clearance (Cl) and the apparent steady-state volumes of distribution (V<SUB>ss</SUB>) for T-2 toxin were 0.662 L kg<SUP>-1</SUP> and 0.038 L/min/kg. This study demonstrated that T-2 toxin is rapidly removed from the blood followed by its fast conversion to metabolites.}
    }