@article{MAKHILLJAVA20121183348,
    title = {Polymorphism of <I>BMP2</I> Gene Associated with Growth Traits in Guizhou Semi-Fine Wool Sheep},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {8},
    pages = {1110-1115},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.1110.1115},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.1110.1115},
    author = {Xiao Yun Shen,Li Juan,Yong Jun Li,Wen Ting Li and},
    keywords = {BMP-2 gene,Guizhou Semi-Fine Wool sheep,growth traits,body height,China},
    abstract = {Bone Morphogenetic Protein 2 (BMP2) plays a crucial role in bone growth. The objective of this study was to investigate variations in sheep <I>BMP2</I> gene and their associations with growth traits in 320 Guizhou Semi-Fine Wool sheep. Five fragments of <I>BMP-2</I> gene were investigated only exon2 region of <I>BMP-2</I> gene showed polymorphism after PCR-SSCP and DNA sequencing methods. There was one G&gt;A (g. 273 G&gt;A) mutation located in nucleotide position of GenBank Accession No. EU854586 which constructed three genotypes (LL, LW and WW). The frequencies of allele L and genotype LL were dominant in Guizhou Semi-Fine Wool sheep. The PIC (Polymorphism Information Content) values of the Guizhou Semi-Fine Wool sheep were 0.3261 belong to median polymorphism. Associations between growth traits and <I>BMP2</I> gene polymorphism were investigated and significant statistical association results were found in body height, body length and chest circumference (p&lt;0.05). These results strongly suggested that the <I>BMP2</I> gene is a candidate gene that influences growth traits in Guizhou Semi-Fine Wool sheep. Further investigations are required for detecting the polymorphism of this gene in a broad variety of sheep breeds and populations.}
    }