@article{MAKHILLJAVA201110253163,
    title = {Alterations in Growth Related Genes (<I>GH-I</I>, <I>IGF-I</I> and <I>IGF-II</I>) Expression with Acute Copper Exposure in Rainbow Trout},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {25},
    pages = {3334-3339},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.3334.3339},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.3334.3339},
    author = {Ercument,Saltuk Bugrahan,Sukru and},
    keywords = {Copper,growth hormone,insulin like growth factors,gene expression,multiplex real-time PCR,rainbow trout},
    abstract = {In this study, the acute effects of copper (CuSO<SUB>4</SUB>.5H<SUB>2</SUB>O) on the expression of Growth Hormone-I (GH-I) and Insulin like Growth Factors I and II (IGF-I and IGF-II) were investigated in rainbow trout (<I>Oncorhynchus mykiss</I>) muscle tissue. For this purpose, rainbow trout were exposed to 100 &#956;g L<SUP>-1</SUP> (Sublethal concentration) copper sulfate in moderately hard freshwater. After 6, 12, 24 and 48 h of treatment, expression of white muscle GH-I, IGF-I and IGF-II mRNAs were measured by means of quantitative real-time PCR. During the exposure experiments, no mortalities occurred. All mRNA levels significantly decreased after copper administration (p&lt;0.05). The results indicate that short term copper exposure suppresses the mRNA expression levels of GH-I, IGF-I and IGF-II in rainbow trout muscles.}
    }