@article{MAKHILLJAVA201110233113,
    title = {Expression Differentiation of <I>BPI</I> Gene in Post-Weaning Piglets of Yorkshire, Sutai and Meishan Breeds},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {23},
    pages = {3155-3160},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.3155.3160},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.3155.3160},
    author = {J.,C.,X.M.,L.,Z.D.,L.,K.Z.,X.G.,S.L. and},
    keywords = {BPI gene,gene expression,pig,real-time PCR,bacteria,human},
    abstract = {The Bactericidal/Permeability-Increasing protein (BPI) plays a very important role in the animal body&#146;s natural defense. It has a series of biological functions such as killing Gram-negative bacteria, the neutralization of endotoxin or lipopolysaccharides, etc. To investigate the effect and mechanism of porcine <I>BPI</I> gene on enterotoxigenic <I>Escherichia coli </I>F18, particularly whether the expression of<I> BPI</I> gene is related to the different breeds. In this study, real-time PCR was used to analyze the expression of <I>BPI </I>gene expression in post-weaning piglets of Yorkshire, Sutai (Resource Population of resistance to <I>E. coli</I> F18) and Meishan. The results showed that there was almost no expression or very low expression of <I>BPI</I> gene in heart, liver, spleen, lung, kidney, stomach, muscle, thymus and lymph nodes but there was a high expression in the duodenum and jejunum and the expression levels were significantly different from those of the other 9 organs. It also showed that the jejunum and duodenum expression of <I>BPI </I> gene in Sutai was significant higher than Yorkshire and Meishan (p&lt;0.05). The researchers can speculate that the expression of <I>BPI</I> gene was significant difference in different breeds. The researchers can further indicates that the expression of the <I>BPI</I> gene in Sutai piglets could be beneficial to the infection of <I>E. coli</I>. <I>BPI</I> gene might have a direct role against diarrhea and edema disease caused by ECF18 in weaned piglets, the resistance was related to the upregulation of <I>BPI</I> gene expression in the intestine. <I>BPI</I> gene can be identified as a genetic marker for future breeding against <I>E. coli </I>and Salmonella related diseases.}
    }