@article{MAKHILLJAVA201110223039,
    title = {Effect of Long-Term Dietary Lipids on Femur Mineral Content, <I>Ex vivo</I> Prostaglandin E<SUB>2</SUB> Release and Bone Growth in Growing Rabbits},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {22},
    pages = {2943-2955},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.2943.2955},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.2943.2955},
    author = {D.M. and},
    keywords = {É-6 and É-3 PUFAs,bone minerals,prostaglandin,E2bone growth,growing rabbits,Saudi Arabia},
    abstract = {The long-term effects of different dietary oil sources with varying omega-6/omega-3 (&#969;-6/&#969;-3) Polyunsaturated Fatty Acids (PUFAs) ratios on the bone marrow fatty acids level, bone growth and <I>ex vivo</I> Prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) release and minerals content in bone were evaluated in rabbits. Weanling male and female New Zealand white rabbits were randomly assigned to five groups and fed <I>ad libitum</I> on diets containing 70 g kg<SUP>-1</SUP> of added oil for 100 days as follow; Soybean Oil (SBO control), Sesame Oil (SO), Fish Oil (FO), DHA algae oil (DHA) and DHA and ARA algae oils (DHA/ARA). The dietary lipid treatments were formulated to provide the following ratio of &#969;-6/&#969;-3 fatty acids: 8.7 (SBO), 21.8 (SO), 0.4 (FO), 0.6 (DHA) and 0.7 (DHA/ARA). The bone marrow fatty acids level of rabbits was significantly influenced by and reflected the dietary level of &#969;-6 and &#969;-3 fatty acids fed to rabbits. Rabbits fed the FO diet maintained a lower &#969;-6/&#969;-3 ratio and a higher EPA and DHA concentrations in their bone marrow those fed the SO diet maintained a higher &#969;-6/&#969;-3 fatty acids ratio while those fed the SBO diet maintained a higher LA and ALA concentrations and intermediate value of &#969;-6/&#969;-3 ratio. <I>Ex vivo</I> PGE<SUB>2</SUB> level declined progressively as the &#969;-6/&#969;-3 dietary ratio declined. There was a significant main effect of dietary treatment on femur Ca, P, Mg and Zn contents in both genders. These results demonstrate that dietary &#969;-6/&#969;-3 ratio modulates bone PGE<SUB>2</SUB> production in growing rabbits, hence may reduce bone resorption and improve bone mass during growth. In addition, the significant elevation in mineral content and the maintenance of optimal Ca/P ratio in bone of DHA/ARA and DHA fed groups demonstrates that marine algae oils may be promising dietary sources for promoting bone mineralization and formation thus improving bone mass during the growth stage.}
    }