@article{MAKHILLJAVA201110203026,
    title = {Postnatal Development of <I>IGF-I</I> and <I>IGF-II</I> Genes in Goat Skeletal Muscle and Liver Tissues},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {20},
    pages = {2745-2750},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.2745.2750},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.2745.2750},
    author = {Linjie,Li,Bo and},
    keywords = {skeletal muscle,Goat,Nanjiang Mongolian Grazelle,IGF-I,IGF-II,liver},
    abstract = {Insulin like Growth Factors (IGF-I and IGF-II) play an important role in regulation of skeletal muscle growth and act as mediator of growth hormone during muscle development and differentiation. In this study, the expression profiling of goat <I>IGF-I</I> and <I>IGF-II</I> genes was investigated in liver and skeletal muscle at six postnatal development stages (3, 15, 30, 60, 90 and 120 days) and two types of muscles (longissimus dorsi muscle, LD; triceps brachii muscle, TB) using relative real-time quantitative PCR. The results showed that <I>IGF-I</I> gene was expressed at the highest level in the liver with relatively high expression levels in spleen, skeletal muscle and heart. <I>IGF-II</I> gene was predominantly expressed in spleen, followed by liver and longissimus dorsi muscle, whereas expression in heart was relatively weak. <I>IGF-I</I> and <I>IGF-II</I> genes had different expression profiles during the postnatal period of the goat liver and skeletal muscle development. Moreover, <I>IGF-I</I> was expressed at higher levels in triceps brachii muscles compared with longissimus dorsi muscles. The present study provided the comprehensive understanding of IGF-I and IGF-II expression during liver and muscle development and laid the basis for further studies on their roles in goat liver and skeletal muscle development.}
    }