@article{MAKHILLJAVA201110182962,
    title = {<I>In vitro</I> Pharmacodynamics of Enrofloxacin Against an <I>Escherichia coli gyrA</I> Mutant},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {18},
    pages = {2384-2388},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.2384.2388},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.2384.2388},
    author = {Ali,Erdem and},
    keywords = {Turkey,Pharmacodynamic of enrofloxacin,Escherichia coli,C-T mutation,microdilution,significant},
    abstract = {The aim of this study was to investigate <I>in vitro</I> the pharmacodynamics of Enrofloxacin (ENR) against an <I>Escherichia coli gyrA</I> mutant (<I>E. coli </I>MT/128). Broth microdilution testing was used to determine the Minimum Inhibitory Concentration (MIC) amd multi-step resistance selection was performed until reaching 1 &#956;g mL&#8226;<SUP>1</SUP> MIC. For time-kill experiments, colony counts were determined by plating each diluted sample onto Plate Count Agar and an integrated pharmacokinetic/pharmacodynamics area measure (log ratio area) was applied to all cfu data. A single C-T mutation was found in gyrA at codon 83. Concentration-dependent bacterial killing was observed for <I>E. coli </I>MT/128. Bactericidal activity for this strain was achieved within 4 h at concentrations &#8226; 8 times the MIC with no significant regrowth by 24 h.}
    }