@article{MAKHILLJAVA201110162913,
    title = {Expression Analysis of <I>HIF-1&#945;</I> and <I>HIF-2&#945;</I> Genes in Tibetan Chicken under Normoxia and Hypoxia},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {16},
    pages = {2172-2175},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.2172.2175},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.2172.2175},
    author = {M.,J.B.,X.X.,Y. and},
    keywords = {hypoxia,normoxia,HIF-2a,HIF-1a,Tibetan chicken,adaptability},
    abstract = {Tibetan chicken is one of those chicken breeds that could adapt to high altitude and low O<SUB>2</SUB> tension environment; it owes an integrative genetic mechanism for hypoxia adaptability compared to lowland chicken breeds. HIF-1&#945; and HIF-2&#945; are the central factors playing important roles in maintaining organisms&#146;s oxygen homeostasis. In this study, the expression of <I>HIF-1&#945;</I> and <I>HIF-2&#945;</I> genes were investigated by Real Time-PCR in Tibetan chicken and Dwarf chicken embryo brain tissue under normoxia (21% oxygen concentration) and hypoxia (13% oxygen concentration). The results showed that Tibetan chicken always had lower mortality than Dwarf chicken during the incubation. We also detected higher HIF-&#945;s expression at the late of incubation (18th day) compared with that at 12th day in all tested samples; we further obtained the expression pattern of <I>HIF-&#945;s</I> genes in dead embryos was opposite to that in live embryos.}
    }