@article{MAKHILLJAVA201110142867,
    title = {Polymorphism Identification and Association Analysis of <I>IRF3</I> Gene in Pig},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {10},
    number = {14},
    pages = {1841-1844},
    year = {2011},
    issn = {1680-5593},
    doi = {javaa.2011.1841.1844},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2011.1841.1844},
    author = {Like,Zhihua,Deyi,Shenghe,Xunsheng and},
    keywords = {China,Pig,association analysis,PCR-SSCP,polymorphism,IRF3 gene},
    abstract = {In this study, <I>IRF3</I> gene was chosen as a candidate gene for evaluating its effect on porcine immune traits. A SNP (HQ026024: g.4252T&gt;C) in exon7 of <I>IRF3</I> gene was demonstrated by PCR-SSCP analysis and sequencing. Immune traits including IFN-&#947; and IL10 concentrations in serum were measured when the pigs are at 20th day of age. The further association analysis of SNP genotypes with immune traits were also conducted in 3 pig breeds including Large white, Landraces and Chinese indigenous breed Dingyuan black pig. The results indicated that the SNP of <I>IRF3</I> gene had highly significant effects on level of IFN-&#947; and IL10 (day 20) in serum (p = 0.0344; p = 0.0121) and ratio of IFN-&#947; to IL10 (day 20) in serum (p = 0.0315). The results suggested that the <I>IRF3</I> gene could be regarded as a molecular marker gene for genetic selection of these immune traits in the pig breeding program.}
    }