@article{MAKHILLJAVA20109232496,
    title = {Effects of Estrogen Replacement Therapy with Vitamin E on Oxidative Stress in Hepatic and Pancreatic Tissues of Ovariectomized Diabetic Rats},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {9},
    number = {23},
    pages = {2955-2962},
    year = {2010},
    issn = {1680-5593},
    doi = {javaa.2010.2955.2962},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2010.2955.2962},
    author = {Mehmet and},
    keywords = {Ovariectomy,estrogen,vitamin E,MDA,AST,ALT},
    abstract = {We investigate the effects of 17&#946;-estradiol (E<SUB>2</SUB>) and vitamin E on oxidative stress of hepatic and pancreatic tissues in Ovariectomized (OVX) diabetic rats. Fortynine rats were equally divided into seven groups: Control; OVX; OVX+E<SUB>2</SUB>; OVX+E<SUB>2</SUB>+Vitamin E; OVX+Diabetic; OVX+Diabetic+E<SUB>2</SUB> and OVX+Diabetic+E<SUB>2</SUB>+Vitamin E. The Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and vitamin A and &#946;-carotene in liver and pancreas were reduced when compared with control but Malondialdehide (MDA) was raised. E<SUB>2 </SUB>and E<SUB>2</SUB>+vitamin E supplementations to OVX rats increased GSH-Px, SOD, CAT, GSH, vitamin A and &#946;-carotene in liver and pancreas but decreased MDA. MDA in liver and pancreas, Aspartate amino Transferase (AST), Alanine amino Transferase (ALT), Lactate Dehydrogenase (LDH), &#946;-glutamyl Transferase (GGT) and Alkaline Phosphatase (ALP) in the serum of diabetic OVX rats were raised when compared with OVX but the activities antioxidant enzyme, GSH, vitamin A and &#946;-carotene in liver and pancreas were lowered. The GSH-Px, SOD, CAT, GSH, vitamin A and &#946;-carotene in liver and pancreas increased, although MDA in liver and pancreas and AST, ALT, LDH, GGT and ALP in serum decreased in diabetic OVX after E<SUB>2</SUB> and E<SUB>2</SUB>+vitamin E supplementation.}
    }