@article{MAKHILLJAVA20109222479,
    title = {Functions of CLA and ARA for Prevention of CCl<SUB>4</SUB>-Induced Fatty Liver in Mice},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {9},
    number = {22},
    pages = {2854-2858},
    year = {2010},
    issn = {1680-5593},
    doi = {javaa.2010.2854.2858},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2010.2854.2858},
    author = {Daichi,Yoriko,Yurika,Shoichiro and},
    keywords = {Conjugated linoleic acid,arachidonic acid,mice,carbon tetrachloride,hepatitis,prostaglandin E2},
    abstract = {Oral administration of carbon tetrachloride (CCl<SUB>4</SUB>) induces acute hepatitis while Prostaglandins (PGs) are proposed to attenuate liver injury. Conjugated Linoleic Acid (CLA) influences the synthesis of PGs and Arachidonic Acid (ARA) is a precursor of PGs. Therefore, whether CLA or ARA attenuates the hepatitis induced by CCl<SUB>4</SUB> was investigated in mice. Male mice (age, 8 week) were given commercial diet and combinations of paraffin or CCl<SUB>4</SUB> solution with or without CLA or ARA oil were orally administered. Food intake and body weight were significantly reduced in the CCl<SUB>4</SUB> group. Although, no significant changes in liver weight were observed, liver triacylglycerol contents in the CCl<SUB>4</SUB>+CLA and CCl<SUB>4</SUB>+ARA groups were markedly higher than those in groups other than the CCl<SUB>4</SUB> group. Plasma AST and ALT levels were unusually elevated after CCl<SUB>4</SUB> administration irrespective of oil treatment. CCl<SUB>4</SUB>+ARA treatment greatly increased PGE<SUB>2</SUB> content in the liver and followed by CCl<SUB>4</SUB>+CLA treatment. In conclusion, co-administration of CLA and ARA enhanced liver PGE<SUB>2</SUB> levels after CCl<SUB>4</SUB> treatment but acute hepatitis was not attenuated.}
    }