@article{MAKHILLJAVA200985798,
    title = {The Effects of Epigallocatechin Gallate and N-Acetylcysteine on Mobile Phone-Induced Oxidative Stress in Guinea Pigs},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {8},
    number = {5},
    pages = {959-961},
    year = {2009},
    issn = {1680-5593},
    doi = {javaa.2009.959.961},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2009.959.961},
    author = {Gorkem Kismali,Elcin Ozgur,Serkan Sayiner,Burcu Alpaslan,Goknur Guler,Nesrin Seyhan and},
    keywords = {Epigallocatechin gallate,n-acetylcysteine,oxidative stres,mobile phone,guinea pigs,MDA},
    abstract = {It has been reported that mobile phones induce free radical formation. Epigallocatechin Gallate (EGCG) and N-Acetylcysteine (NAC) were recently found to be potent antioxidants. The present study was carried out to determine the protective effects of antioxidants namely EGCG and NAC against the mobile phone-induced oxidative stress. Three-month-old male Guinea pigs were randomized into 6 groups; sham group, not exposed to mobile phone, NAC group (300 mg kg<SUP>-1</SUP> ip, 7 days), 10 min mobile phone-exposed group with NAC, 10 min mobile phone-exposed group, EGCG group (25 mg kg<SUP>-1</SUP> ip, 7 days) and 10 min mobile phone-exposed group with EGCG. During the exposure external E fields were measured by NARDA EMR 300 and type 8.3 probe. Guinea pigs were exposed to RFR averaged as 11.2&plusmn;0.5 V m<SUP>-1</SUP> for 10 min/day/7days. Malondialdehyde (MDA, an index of lipid peroxidation) were analysed as markers of oxidative stress. Plasma MDA levels increased in mobile phone exposed guinea pigs while EGCG causes a significant reduction of MDA levels, whereas NAC caused a significant increase in MDA levels. Also, MDA levels in mobile phone exposure group significantly increased with respect to sham exposure group. A number of studies have identified antioxidant species which show antioxidant effect in low-dose and pro-oxidant behaviour in high-dose. The increase of the lipid peroxidation at the treatment dose of NAC in guinea pigs may possibly be due to pro-oxidant behaviour. Besides, this study expressed that mobile phone exposure affect the level of lipid peroxidation of plasma.}
    }