@article{MAKHILLJAVA200985795,
    title = {Effects of Copper and Zinc on Cathepsin B Activity in Equine Articular Chondrocytes},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {8},
    number = {5},
    pages = {935-945},
    year = {2009},
    issn = {1680-5593},
    doi = {javaa.2009.935.945},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2009.935.945},
    author = {Gustavo Hernandez Vidal,Jorge R. Kawas Garza,Rafael Ramirez Romero,Luis E. Rodriguez Tovar,Alicia M. Nevares Garza,Francisco A. Mora Valdez,Jesus J. Hernandez Escareno,Elisabeth Davis and},
    keywords = {Horse,cathepsin B,enzymatic activity,copper,zinc,chondrocytes,proteoglycan,articular cartilage and dyschondroplasia},
    abstract = {The effects of copper and zinc on cathepsin B activity, chondrocytes behaviour and matrix turnover by articular cartilage were investigated <I>in vitro </I>using normal horse cartilage co-cultured with synovial tissue. Proteoglycan (PG) depletion was assessed by toluidine blue staining. Co-culture cartilage expressed elevated levels and activity of the PG-degrading enzyme cathepsin B. Copper but not zinc was able to reduce the depletion of PG and the enzyme activity induced by the synovial tissue.}
    }